Variation in Ligand Dependent Activation of Steroid and Xenobiotic (SXR) Single Nucleotide Polymorphisms
نویسنده
چکیده
F a c u l t y M e n t o r When she became interested in performing research, Emily Grossman contacted Professor Blumberg, who put her under the guidance of Dr. Matthew Milnes, a postdoctoral researcher in his lab. Emily’s work focuses on a nuclear hormone receptor that is vital in de-toxifying the body and is responsible for the regulation of the metabolism of over 60% of currently used pharmaceutical drugs. She has enjoyed working with the people in her lab and learning new techniques and protocols. Completing projects on her own has increased her confidence in her abilities. Emily will move on to graduate school in September 2007. Variation in Ligand Dependent Activation of Steroid and Xenobiotic (SXR) Single Nucleotide Polymorphisms
منابع مشابه
Activation of Steroid and Xenobiotic Receptor (SXR, NR1I2) and Its Orthologs in Laboratory, Toxicologic, and Genome Model Species
BACKGROUND Nuclear receptor subfamily 1, group I, member 2 (NR1I2), commonly known as steroid and xenobiotic receptor (SXR) in humans, is a key ligand-dependent transcription factor responsible for the regulation of xenobiotic, steroid, and bile acid metabolism. The ligand-binding domain is principally responsible for species-specific activation of NR1I2 in response to xenobiotic exposure. OB...
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